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KMID : 0352719940180010017
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Journal of Ginseng Research
1994 Volume.18 No. 1 p.17 ~ p.24
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Effect of Ginseng Components (Ginsenosides and Fat Soluble Fraction) on Rat Liver Glucokinase Activity
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Abstract
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Abstract□Effect of ginsenoside mixture, ginsenoside Rb1, Rb2, Rg1 and the fat soluble fraction of the roots of Panax ginseng C.A. Meyer on The activity of glucokinase (GK) in vitro has been observed and found that GK activity was increased about
15% at
the concentration of ginsenoside mixture and/or the fat soluble fraction being 10-7~10-5%. It was also observed that glucose uptake by rat liver was increased in the presence of either ginsenoside mixture or the fat soluble fraction by perfusion
technique. Ginsenoside mixture stimulated various enzymes related to glucose metabolism, however, both ginsenoside mixture and the fat soluble fraction did not stimulate GK activity as expected. Primary culture of liver cells showed that the
ginsenoside
mixture and the fat soluble fraction increased GK activity significantly and they stimulated the GK activity synergistically in the co-presence of insulin.
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KEYWORD
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